Autophagy by Daniel J. Klionsky

By Daniel J. Klionsky

Klionsky (life sciences, U. of Michigan, Ann Arbor) defines "autophagy" as "a procedure during which the cellphone more often than not undergoes membrane rearrangement to sequester a component to cytoplasm, carry it to a degradative organelle and recycle the macromolecular ingredients. He argues that, within the conventional view of organelles as mobile rubbish disposals, the continued force towards homeostatis among mobile dying and synthesis has been missed. His advent additionally lists the recent nomenclature for 27 autophagy-related genes. In 22 different chapters, overseas members evaluate autophagy in organisms from yeast to people and its roles in metabolism, getting older, melanoma and neuromuscular illnesses. a few photos are in colour.

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Phagophores visualized by electron microscopy. Isolated rat hepatocytes were processed for conventional (epon) electron microscopy (A and B), or purified hepatocytic autophagosomes were freeze-fractured and shadowed with platinum (C and D). Phagophores in the process of engulfing cytoplasm could be found in both preparations, although they are a rare occurrence among the purifed autophagosomes. Bar length, 150 nm (A,B) or 250 nm (C,D). B-D, modified from refs. 6 and 4. tophagy is a constitutive rather than an inducible process, regulated on a short-term basis by changes in activity.

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Wang C-W, Stromhaug PE, Shima J et al. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 2002; 277:47917-47927. 96. Tanaka Y, Guhde G, Suter A et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 2000; 406:902-906. 97. Suriapranata I, Epple UD, Bernreuther D et al. The breakdown of autophagic vesicles inside the vacuole depends on Aut4p. J Cell Sci 2000; 113:4025-4033. 98. Epple UD, Suriapranata I, Eskelinen E-L et al.

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